Technology

Regentis has developed a technology platform called Gelrin™ for tissue regeneration. Gelrin™ is an in-situ photopolymerizable hydrogel material comprised of polyethylene glycol (PEG) polymer, cross-linked with denatured fibrinogen. Gelrin™ implant is designed to degrade overtime and gradually be replaced by healthy functional tissue.

The Gelrin™ hydrogel implant is gradually degraded by the enzymatic action of proteases acting on the denatured fibrinogen and by hydrolysis of the PEG chains. The dense hydrogel network formed by the PEG chains limits protease infiltration and causes the implant to erode slowly. The Gelrin properties provide a biodegradable void filling matrix designed to guide migration of cells involved in tissue repair.

The Gelrin's liquid precursor can be polymerized into a hydrogel either in-situ or ex-vivo, depending on the application. The ability to form this material in-situ at the site of the defect facilitates use of the device in minimally invasive surgical procedures, while the use of pre-cast shapes for more complex operations by ex-vivo formation is also possible.

The Gelrin™ material becomes a gel by photopolymerization with UV light;
it can be molded into any shape and size, or injected directly into the injury
site and polymerized in-situ.

Caution: Investigational Device. Limited by U.S. law to investigational use.